The Acoustocerebrograph

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World First: Non-Invasively Classifying Brain Tissue

Sonovum AG has been able to develop an ACG device that will revolutionize research, diagnosis and treatment options in many different medical applications.

With our new Acoustocerebrographs, for the first time we are able to permanently and repeatedly display states and processes that take place in our heads, completely risk-free – unlike the snapshots from imaging techniques such as MRI or CT. In our heads, liquids and tissue are subject to constant movement. In case of a stroke or other neurological complications, these movement patterns change in distinctive ways. Thanks to their highly sensitive acoustic sensors, our ACG devices can recognise these patterns and make the changes heard.

The Acoustocerebrograph

Sonovum - Der Akustocerebrograf
The Acoustocerebrograph – a game changer in ultrasound diagnostics

Sonovum AG has been able to develop an ACG device that will revolutionize research, diagnosis and treatment options in many different medical applications.

With our new Acoustocerebrographs, for the first time we are able to permanently and repeatedly display states and processes that take place in our heads, completely risk-free – unlike the snapshots from imaging techniques such as MRI or CT. In our heads, liquids and tissue are subject to constant movement. In case of a stroke or other neurological complications, these movement patterns change in distinctive ways. Thanks to their highly sensitive acoustic sensors, our ACG devices can recognise these patterns and make the changes heard.

We feel the sound of mind!

Sonovum AG’s non-invasive Acoustocerebrograph uses research results from Molecular Acoustics coupled with a set of powerful deep learning algorithms. It measures density, attenuation and sound velocity of the fluids and tissues in the brain. In essence, two parameters are determined: the relative transit time (RTI) and the attenuation (ATN) of the acoustic wave.

The device consists of two ultrasonic transducers joined by a strap (similar to a headset) positioned on the patient's head, and an output device that displays the measurement data.

The ACG device is a class 2a medical product according to MDD.

Clinical Partners' Testimonials

As a data collector, ACG records the brain status in intervals. It can also display these results instantaneously in an acute diagnosis setting. Furthermore, snapshot results can be compared to each other over time. For the first time, this enables us to create a close-knit mesh of data points in order to understand obscure long-term changes. Accumulating over time, these changes should be detectable sooner with ACG, reducing cost and suffering.

Sonovum AG
Sonovum AG

In our first Acoustocerebrography (ACG) trial, we focused on prevention in a group of patients with a high risk of stroke: we compared MRI measurements with ACG results, assessing the number and correlation of White Matter Hyperintensities (or White Matter Lesions, WML). On top of that, we compared results obtained from patients with a combination of Atrial Fibrillation (AF) and hypertension (HT) with those from AF patients without HT. Finally, we looked at HT patients with regard to any problematic changes in brain tissue.

In conclusion, we can say that ACG is a very promising method to assess brain tissue changes in patients with AF, HT or a combination of both at an early stage. Furthermore, it is suitable for detecting White Matter Hyperintensities in patients with AF. ACG could be increasingly significant in diagnosing AF and HT patients in order to individualise their treatment and/or to noticeably reduce their risk of stroke.

Extracts from relevant studies and publications

Olszewski et al: "Is Acoustocerebrography a new noninvasive method for early detection of the brain changes in patients with hypertension?"; Poster accepted for European Society of Cardiology Conference, August 2017, Barcelona

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Schmude: "Detecting Changes in the Human Brain caused by Atrial Fibrillation using Ultrasound and Deep Learning"; Poster presented at European Stroke Conference, May 24, 2017, Berlin; E-Poster Ref. No. L 022

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Dobkowska-Chudon et al: "Utilizing Comparison Magnetic Resonance Imaging and Acoustocerebrography Signals in the Assessment of Focal Cerebral Microangiopathic Lesions in Patients with Asymptomatic Atrial Fibrillation (Preliminary Clinical Study Results)", EAA 2016 Congress, Jastrzębia Góra, Poland

in: Archives of Acoustics 2016, Volume 41, Issue 2

Abstracts as PDF

Bogdan et al: Computer Aided Multispectral Ultrasound Diagnostics Brain Health Monitoring System based on Acoustocerebrography, Conference Paper submitted for MEDICO 2016, Cyprus

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Wrobel et al: “On ultrasound classification of stroke risk factors from randomly chosen respondents using non-invasive multispectral ultrasonic brain measurements and adaptive profiles”, Biocybernetics and Biomedical Engineering 2015, Volume 35, Issue 4

Download PDF Full Article

Areas of application

Potential

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The procedure and range of options offered by this device are to a certain extent, unlimited. We have already explored some applications; many others have also been hypothesized.

The interpretation of the measurement results has not yet been fully correlated with clinical data. Cooperation with a variety of specialized doctors using the ACG device suggests that new medical findings can be discovered and explored.

Contact us and become a research partner!

An overview of our research partners

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Sonovum AG
Perlickstraße 5 | 04103 Leipzig


+49 341 39299-510

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Sonovum AG
Perlickstraße 5
04103 Leipzig

Telephone: +49 341 39299-510
E-mail: ###EMAILADDR-INFO-AT-SONOVUM###

Sales tax identification number according to §27 German Sales Tax Law: DE281226472
Commercial Registered - Leipzig Court: HRB 27913

Responsible according to § 55 section 2 RStV and TMG: Miroslaw Wrobel

Supervisory Board: Miroslaw Wrobel
Supervisory Board Chairman: Hans-Jürgen Heiser

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